11beta hydroxysteroid dehydrogenase type 1 inhibitors a review of recent patents

When tested in vitro , 7-keto appears to activate the beta subset of the estrogen receptor (ERβ) with an EC 50 around 500μM which is partially blocked by exemestane (aromatase inhibitor or AI); there was no apparent activity on the classical subset (ERα) and parent DHEA and DHEAS were eqipotent. [45] As activity was hindered with an AI and there was efficacy in HepG2 cells but not Hep293 (expressing [46] and not expressing [47] aromatase, respectively) it is though that 7-oxo can be metabolized into an estrogen. [45]

11beta hydroxysteroid dehydrogenase type 1 inhibitors a review of recent patents

11beta hydroxysteroid dehydrogenase type 1 inhibitors a review of recent patents

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11beta hydroxysteroid dehydrogenase type 1 inhibitors a review of recent patents11beta hydroxysteroid dehydrogenase type 1 inhibitors a review of recent patents11beta hydroxysteroid dehydrogenase type 1 inhibitors a review of recent patents11beta hydroxysteroid dehydrogenase type 1 inhibitors a review of recent patents11beta hydroxysteroid dehydrogenase type 1 inhibitors a review of recent patents

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