It seems strange, then, that allergic reactions to corticosteroids actually occur—especially since these medications are used to treat allergic reactions. While severe allergic reactions to corticosteroids are extremely rare, they do in fact occur. Most allergic reactions to corticosteroids are less severe, however, and result from the topical formulations—occurring in up to 6% of people. Allergic reactions to oral or injected formulations are rarer, occurring in less than 1% of people. Causes of allergic reactions to corticosteroids may be due to IgE antibodies , or as a result of delayed-type hypersensitivity reactions caused by T-cells (a type of white blood cell).
NSAIDS have antipyretic activity and can be used to treat fever.   Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation.   Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus .   PGE2 signals to the hypothalamus to increase the body's thermal set point.   Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen).   Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.
Sinusitis can be caused by viral infections such as cold, allergies, nasal polyps, hay fever, and other abnormalities of nose and sinus cavities. Patients with sinusitis may experience bad breath, cough, fever, nasal congestion discharge of mucous, toothache, and swelling of the face. Other symptoms include nausea, headache, sore throat, and pain behind the ears. Acute sinusitis may be caused due to common cold and allergies and the symptoms may last up to 4 weeks. Chronic sinusitis results from asthma or allergies and recurrent acute sinusitis where the symptoms may last up to 3 months or longer.