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12 th Pharmaceutical Sciences and Pharma Industry Conference February 26-27, 2018, London , UK; 7th European Biosimilars Conference , April 26-27, 2018, Rome, Italy ; 10 th Pharmacology Conferences during July 30-Aug 01, 2018 at Barcelona, Spain ; 4 th Marine Drugs and Natural Products Conferences , June 11-13, 2018 at Rome , Italy; 8 th Environmental Chemistry Conference , September 20-22, 2018 Berlin, Germany ; 9 th Pharmacovigilance Exhibition , June 21-22, 2018 at London, UK ; 4 th Antibiotics Conference ; June 14-15, 2018, Barcelona , Spain

2-Methoxyestradiol exhibits the inhibitory activity of cellular proliferation in a breast carcinoma cell line MDA-MB-435 and an ovarian carcinoma cell line SK-OV-3 with IC50 of μM and μM, respectively. Furthermore, 2-Methoxyestradiol also inhibits cellular microtubule depolymerization in rat aortic smooth muscle A-10 cells with EC50 of μM. [1] 2-Methoxyestradiol inhibits proliferation of MCF-7 and BM cells with IC50 of 52 μM and 8 μM. [2] In MDA-MB-231 cells, 2-Methoxyestradiol inhibits HIF-1-mediated transcriptional activation of target genes without affecting the transcription of HIF-1α itself. [3] A recent study shows that 2-Methoxyestradiol ( μM), blocks TGF-β3-induced expression of collagen (Col) type I(αI), Col III(αI), plasminogen activator inhibitor (PAI) 1, connective tissue growth factor (CTGF), and α-smooth muscle actin (α-SMA). Moreover, 2-Methoxyestradiol ameliorates TGF-β3-induced Smad2/3 phosphorylation and nuclear translocation, and inhibits TGF-β3-induced activation of the PI3K/Akt/mTOR pathway. [4]

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Mass 600 steroid

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