Organelle that prepares proteins for export and synthesizes steroids

Adipose , Adrenal Gland , Aorta , Bladder , Blood Vessel , Bone , Brain , Cartilage , Cecum , Colon , Cranium , Diaphragm , Duodenum , Ear , Epithelium , Eye , Feces , Fish Organs , Gallbladder , Genital Warts , Heart , Hypothalamus , Intestinal Mucosa , Intestine , Jaw , Jejunum , Kidney , Larynx , Liver , Lung , Lymph Node , Marrow , Meconium , Mouse Femur and Tibia , Muscle , Nasal , Olfactory Mucosa , Oropharynx , Pancreas , Peritoneal Macrophages , Pharynx , Pituitary Gland , Placenta , Polyp , Salivary Gland , Skin , Spleen , Stomach , Tail Snips , Teeth , Testes , Thalamus , Thymus Gland , Thyroid Gland , Tongue , Trachea , Tumor , Umbilical Cord , Uterus , Wound Tissue Lyse Cells Bacteria , Yeast (C. albicans) , E. coli , Mammalian cell culture , Stem Cells , Yeast (S. cerevisiae)

Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors . The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element . Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors.

Organelle that prepares proteins for export and synthesizes steroids

organelle that prepares proteins for export and synthesizes steroids

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