Adipose , Adrenal Gland , Aorta , Bladder , Blood Vessel , Bone , Brain , Cartilage , Cecum , Colon , Cranium , Diaphragm , Duodenum , Ear , Epithelium , Eye , Feces , Fish Organs , Gallbladder , Genital Warts , Heart , Hypothalamus , Intestinal Mucosa , Intestine , Jaw , Jejunum , Kidney , Larynx , Liver , Lung , Lymph Node , Marrow , Meconium , Mouse Femur and Tibia , Muscle , Nasal , Olfactory Mucosa , Oropharynx , Pancreas , Peritoneal Macrophages , Pharynx , Pituitary Gland , Placenta , Polyp , Salivary Gland , Skin , Spleen , Stomach , Tail Snips , Teeth , Testes , Thalamus , Thymus Gland , Thyroid Gland , Tongue , Trachea , Tumor , Umbilical Cord , Uterus , Wound Tissue Lyse Cells Bacteria , Yeast (C. albicans) , E. coli , Mammalian cell culture , Stem Cells , Yeast (S. cerevisiae)
Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors . The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element . Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors.