Andrology's July 2016 issue is devoted to the timely topic of endocrine disruption, which is suspected to be one of the factors responsible for the reported rise in the incidence of male reproductive disorders. The content of this special issue highlights some of the pertinent topics in the field that are of relevance for andrologists and researchers interested in reproductive biology and endocrinology, including female reproduction and neuroendocrinology.
The second isoenzyme of 5α reductase is deficient in the classic intersex condition ( pseudovaginal perineoscrotal hypospadias ), or 5α-reductase deficiency . It was first discovered in indigenous cultures of Papua, New Guinea , where children were born with feminine genitalia in the absence of endogenous DHT during pregnancy, but with the surge of testosterone during adolescence, changed to males at puberty. Because of this change at puberty, the condition is also sometimes called " guevedoche ."  There is a range of external appearance that has been described of external genitalia at birth, with varying degrees of virilization.